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Studying Approaches to IVF Treatment
 
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ABOUT THE STUDY

NatPro is a study investigating two different approaches to the management of frozen embryo transfer during IVF treatment. The study will compare 'modified natural cycle' and 'programmed cycle' approaches to find out whether there are differences in how often women become pregnant and how often pregnant women experience preeclampsia.

The two most commonly used protocols for frozen embryo transfer are the natural (Nat) and the programmed (Pro) cycles. With the modified natural cycle, the dominant follicle (sac of fluid in the ovary which develops during ovulation) produces the hormones estradiol (estrogen) needed to thicken the uterine lining in preparation for embryo transfer. With the programmed cycle, the ovary does not produce estradiol and instead a woman is asked to take estradiol to thicken the uterine lining.

The full title of the study is Multi-center, parallel-group, randomized controlled trial of modified natural versus programmed cycles for frozen embryo transfers and their association with preeclampsia and live births.

WHO MAY BE ELIGIBLE

Women may be eligible for this study if they:

PROTECTING STUDY PARTICIPANTS

There are strict laws governing the conduct of clinical studies. A process called informed consent ensures that participants know all the facts regarding the study prior to enrolling. Women who decide to participate will sign an informed consent document. This document is not a contract, and women may withdraw from the study at any time.

All participants will be monitored throughout the study, and a team will be on hand to answer all questions related to the study.

WHAT HAPPENS TO STUDY PARTICIPANTS

Women participating in the study will

Participating women will be compensated for time and effort. The costs of medications and embryo transfer remain the responsibility of the participating women and their insurance companies.

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